#unburdenYourhealth with us

Interpretation of TFT

  • March 22,2021
  • 5 Min Read
Interpretation of TFT

FT3/FT4

TSH↓*

  • Graves’ disease

  • Toxic multinodular goiter

  • Toxic adenoma

  • Thyroiditis (post-viral, post-partum)

  • Iodine deficiency or excess

  • Excess Iodine intake

  • Excess thyroxine ingestion

  • Pregnancy-related (hyperemesis gravidarum; hydatidiform mole)

  • Congenital hyperthyroidism

FT3/FT4

TSH↔ /↓*

  • Non-thyroidal illness

  • Central hypothyroidism

  • Isolated TSH deficiency

  • Assay interference

FT3/FT4

TSH↔ /↑

  • Assay interference

  • Thyroxine replacement therapy

  • Drugs (eg: amiodarone, heparin)

  • Non-thyroidal illness

  • Neonatal period

  • TSH - secreting pituitary adenoma

  • Resistance to thyroid hormone, transportation or metabolism

FT3/FT4

TSH↔ /↑

  • Autoimmune thyroiditis

  • (Hashimoto’s; atrophic)

  • Post-radioiodine therapy/ thyroidectomy

  • Hypothyroid phase of thyroiditis

  • Drugs (amiodarone, lithium, TKIs, ATDs)

  • Iodine deficiency or excess

  • Neck infection

  • Reidel’s thyroiditis

  • Thyroid infiltration (tumour, amyloid)

  • Congenital hypothyroidism

FT3/FT4↔ 

TSH

  • Subclinical hyperthyroidism

  • Poor compliance with thyroxine

  • Malabsorption of thyroxine

  • Drugs (amiodarone)

  • Assay interference

  • Non-thyroidal illness recovery

  • TSH resistance    

FT3/FT4↔ 

TSH↓*

  • Subclinical hyperthyroidism 

  • Recent treatment for hyperthyroidism

  • Drugs (eg: steroids, dopamine)

  • Assay interference

  • Non-thyroidal illness

 

FT3- Free Triiodothyronine; FT4 - Free Thyroxine; TSH - Thyroid Stimulating Hormone

 

Reference:

Koulouri O, Moran C, Halsall D, Chatterjee K, Gumell M. Pitfalls in the measurement and interpretation of thyroid function tests. Best Pract Res Clin Endocrinol Metab. 2013 Dec; 27(6):745-62.

 

Leave a reply

Most Viewed

Premarital Screening

Typhoid

Dengue

Home Quarantine Tips

Vitamin D and Diabetes

Cervical Cancer Screening

COVID-19 Symptoms