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Laboratory or Imaging Tests
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Condition(s)
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Complete Blood Count (CBC)
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Anemia
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Many inflammatory arthritides, especially SLE, RA, IBD and human parvovirus B19 infection
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Polycythemia
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Myeloproliferative disorder
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Thrombocytopenia
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SLE, human parvovirus B19 infection
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Thrombocytosis
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Acute-phase reaction, vasculitis, infection
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Leukopenia
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SLE, RA, Felty's syndrome, Sjogren's syndrome, human parvovirus B19 infection Leukocytosis RA, vasculitis, reactive arthritis, infection
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Absolute Lymphocytosis
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CLPD (polyarthritis can be one of the components of clinical manifestation)
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Eosinophilia
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SLE, RA, IBD, sarcoidosis, dermatomyositis, scleroderma, Churg-Strauss syndrome, PAN, eosinophilic fasciitis, cholesterol emboli
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Chest X-Ray
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- Infiltrates or Nodules
- Serositis
- Upper Lobe Fibrosis
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- RA, sarcoidosis, Wegener's granulomatosis, Churg-Strauss syndrome
- SLE, RA
- Ankylosing spondylitis
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Diffuse Fibrosis
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RA, Scleroderma, Polymyositis
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Joint Aspiration
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Growth on culture
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Infection
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Crystals
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Gout, Pseudogout
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WBC Count
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>2000/mm3 — Inflammation
> 50000/mm3 — Probable infection
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Urinalysis
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Hematuria
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SLE, Wegener's granulomatosis, PAN
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Pyuria
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Reactive polyarthritis (due to UTI)
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Proteinuria
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SLE; Wegener's granulomatosis, amyloidosis
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ECG
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Atrioventricular Block
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Lyme disease, neonatal lupus, ankylosing spondylitis
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APTT/Lupus anticoagulant/APLA
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Prolonged/Present
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SLE, APLA Syndrome
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Rheumatoid Factor
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RA, SLE, Sjogren's syndrome, sarcoidosis, reactive arthritis, PMR, polymyositis, psoriatic arthritis, endocarditis, chronic infections, cancer, chronic liver disease, many nonrheumatic causes
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Anti-CCP Antibody
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RA
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Inflammatory markers
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Infection, most inflammatory arthritides, advanced age, PMR, giant cell arteritis, cancer, anemia, pregnancy; menses
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Antinuclear Antibody
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SLE, RA, scleroderma, Sjogren's syndrome, vasculitis, polymyositis, medications, many nonrheumatic causes
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Elevated SGOT/SGPT
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SLE, PAN, sarcoidosis, hemochromatosis, Sjogren's syndrome, infectious hepatitis, polymyositis
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Elevated ALP
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Bone metastases, Paget's disease, osteomalacia, PMR, ankylosing spondylitis, hyperparathyroidism
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Elevated LDH
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Autoimmune hemolytic anemia, myositis
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dsDNA
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SLE, especially lupus nephritis
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Anti SS-A/Ro, Anti SS-B/La
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Sjogren's syndrome, SLE
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HLA-B27
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Spondyloarthropathies, reactive arthritis
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Elevated Uric Acid
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Gout, psoriatic arthritis, Paget's disease
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False-Positive VDRL
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SLE, APLA Syndrome
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c-ANCA
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Wegener's granulomatosis
|
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Elevated Creatinine
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SLE, Wegener's granulomatosis, vasculitis
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Elevated Creatine Kinase (CPK)
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Polymyositis, dermatomyositis, hypothyroidism
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Elevated Calcium
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Hyperparathyroidism, cancer, sarcoidosis
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