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Thrombophilias: Guide to Hereditary and Acquired Conditions

  • July 16,2022
  • 2 Min Read
Thrombophilias: Guide to Hereditary and Acquired Conditions

Thrombophilias may be hereditary or acquired and the risk/severity of thrombosis varies widely between conditions.

Hereditary Thrombophilia

Relative Risk For A First Venous Thromboembolism (Compared To Community Controls)

Factor V Leiden

  • Heterozygous
  • Homozygous


3x – 7x
80x

Prothrombin G20210A

  • Heterozygous
  • Homozygous



2x – 3x

5x

Double heterozygosity (Factor V Leiden and prothrombin G20210A)

6x

Antithrombin deficiency

5x

Protein C deficiency

4x – 6.5x

Protein S deficiency

1x – 3x

Pseudohomozygous Factor V Leiden

80x

Factor IX Padua

10x

Antithrombin resistance

2x – 3x  

Factor VIII ≥150 IU/dl

3x – 5x

Factor IX ≥129 IU/dl

2.3x

Factor XI ≥121 IU/dl

2x

Adapted from: Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Expert Rev Hematol. 2019 Mar 4;12(3):147–58.

Acquired Thrombophilia

Relative Risk For A First Venous Thromboembolism (Compared To Community Controls)

Antiphospholipid antibody syndrome

3x – 10x

Hyperhomocysteinemia

1.5x – 3x

Surgery

1.7x – 2.8x

Trauma

3x – 5x

Pregnancy

5x – 50x

Estrogen-progestogen therapies

2x – 9x

Cancer

4x – 7x

Myeloproliferative neoplasms

3x

Economy class syndrome (DVT on long haul flights)

2x – 4x 

Obesity (BMI ≥30 Kg/m2)

2x – 3x

Adapted from: Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Expert Rev Hematol. 2019 Mar 4;12(3):147–58.

 

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